反应详情

The preparation is carried out as in Example 7, from 1.2 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride, 1.8 ml of triethylamine, 2 times 0.6 ml of tert-butyl isocyanate and 25 ml of dimethylformamide. After addition of 100 ml of distilled water to the reaction mixture, the precipitate formed is filtered and recrystallized from dimethylformamide. The solid thus obtained is washed with water, then with ethyl ether and dried under reduced pressure (1 mm Hg, 0.13 kPa) at 80° C. There is obtained 0.31 g of 8-(3-tert-butylureido)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a brown solid, the melting point of which is greater than 260° C. (Analysis C18H19N5O2 0.83H2 0.0.03DMF, % calculated C: 64.08, H: 5.68, N: 20.76, % found C: 63.7, H: 5.9, N: 20.6).

1. customthe precipitate formed
2. filtrationis filtered
3. customrecrystallized from dimethylformamide
4. customThe solid thus obtained
5. washis washed with water
6. dry with materialwith ethyl ether and dried under reduced pressure (1 mm Hg, 0.13 kPa) at 80° C