Ammonium Acetate → HCID 19066011, compound

Participants

Reaction Conditions

Reaction Steps

0.76 g of 5-trifluoromethoxy-2-(2-ethoxycarbonyl-1H-imidazol-1-yl)indanone and 19 g of ammonium acetate in 30 ml of acetic acid are heated at reflux for 45 minutes. After cooling to a temperature in the region of 20° C., the precipitate formed is filtered, washed with water and dried under reduced pressure (1 mm Hg, 0.13 kPa) at 40° C. There is obtained 0.5 g of 8-trifluoromethoxy-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a beige powder, the melting point of which is greater than 260° C. (Analysis C14H8F3N3O2.0.9AcOH, % calculated C: 54.73, H: 2.62, F: 18.55, N: 13.68, % found C: 55.0, H: 2.6, F: 18.3, N: 13.8).

Provenance & Evidence