Ammonium Acetate → HCID 19066011, compound

HRID 481461Notes

Reaction equation

HRID 481461 reaction equation
[F:1][C:2]([F:25])([F:24])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=O)[CH:8]([N:14]1[CH:18]=[CH:17][N:16]=[C:15]1[C:19](OCC)=[O:20])[CH2:7]2.C([O-])(=O)C.[NH4+:30]>C(O)(=O)C>[F:25][C:2]([F:1])([F:24])[O:3][C:4]1[CH:12]=[CH:11][C:10]2[C:9]3[NH:30][C:19](=[O:20])[C:15]4[N:14]([CH:18]=[CH:17][N:16]=4)[C:8]=3[CH2:7][C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 19066030HCID 19066030, compound

Product 1

HCID 19066011HCID 19066011, compoundYield 75.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
20 °C

Procedure

0.76 g of 5-trifluoromethoxy-2-(2-ethoxycarbonyl-1H-imidazol-1-yl)indanone and 19 g of ammonium acetate in 30 ml of acetic acid are heated at reflux for 45 minutes. After cooling to a temperature in the region of 20° C., the precipitate formed is filtered, washed with water and dried under reduced pressure (1 mm Hg, 0.13 kPa) at 40° C. There is obtained 0.5 g of 8-trifluoromethoxy-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a beige powder, the melting point of which is greater than 260° C. (Analysis C14H8F3N3O2.0.9AcOH, % calculated C: 54.73, H: 2.62, F: 18.55, N: 13.68, % found C: 55.0, H: 2.6, F: 18.3, N: 13.8).

Workup

  1. temperatureat reflux for 45 minutes
  2. customthe precipitate formed
  3. filtrationis filtered
  4. washwashed with water
  5. customdried under reduced pressure (1 mm Hg, 0.13 kPa) at 40° C

Sources & evidence

ORD record
ord-64074a099f2941159de6cfa3ecc66b3a
Source dataset
uspto-grants-1998_08
Patent number
US05789406

Reaction notes

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