HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → (2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine Dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine | HCID 57058185 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine Dihydrochloride | HCID 70137377 | 36% |
Reaction Steps
To a solution of Compound 19 in CH2Cl2 (10 ml) was added an excess amount of 10% HCl-MeOH (6 ml). After the solvent was evaporated in vacuo, the residual solid was recrystallized from IPA to give Compound 20 (90 mg, 36%; three steps) as a colorless crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789423 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-ff58c4da75c8438f812de679d37af8ce |
| Source note | uspto-grants-1998_08 |