Hydrochloride methanol → (2S,3S)-3-[2-Methoxy-5-[1-(1,3-dithiolan-2-yl)-1-methylethyl]benzyl]amino-2-phenylpiperidine Dihydrochloride

HRID 481545Notes

Reaction equation

HRID 481545 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([CH:25]3[S:29][CH2:28][CH2:27][S:26]3)([CH3:24])[CH3:23])[CH:19]=[CH:18][C:17]=2[O:30][CH3:31])[C@@H:9]1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=O)(C)(C)C.[ClH:38].CO>CCOC(C)=O>[ClH:38].[ClH:38].[CH3:31][O:30][C:17]1[CH:18]=[CH:19][C:20]([C:22]([CH:25]2[S:26][CH2:27][CH2:28][S:29]2)([CH3:24])[CH3:23])=[CH:21][C:16]=1[CH2:15][NH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86752973(2S,3S)-1-tert-Butoxycarbonyl-3-[2-Methoxy-5-[1-(1,3-dithiolan-2-yl)-1-methylethyl]benzyl]amino-2-phenylpiperidine

Product 1

HCID 86752974(2S,3S)-3-[2-Methoxy-5-[1-(1,3-dithiolan-2-yl)-1-methylethyl]benzyl]amino-2-phenylpiperidine Dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of Compound 82 (0.128 g) in EtOAc (5 ml) was added an excess amount of 10% HCl-MeOH (1 ml) for 8 hr. The resulting precipitate was collected and washed with EtOAc to give Compound 83 (0.069 g) as a colorless crystal.

Workup

  1. customThe resulting precipitate was collected
  2. washwashed with EtOAc

Sources & evidence

ORD record
ord-e01711bb15094b529b567ce37b03ca4b
Source dataset
uspto-grants-1998_08
Patent number
US05789423

Reaction notes

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