(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyano-4-oxa-cyclohexyl)-2-methoxybenzyl)amino-2-phenylpiperidine → (2S,3S)-3-(5-(1-Cyano-4-oxa-cyclohexyl)-2-methoxybenzyl)amino-2-phenylpiperidine Dihydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]3([C:28]#[N:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH:19]=[CH:18][C:17]=2[O:30][CH3:31])[C@@H:9]1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=O)(C)(C)C.[ClH:38].Cl.COC1C=CC(C(C2SCCS2)(C)C)=CC=1CN[C@H]1CCCN[C@H]1C1C=CC=CC=1>>[ClH:38].[ClH:38].[C:28]([C:22]1([C:20]2[CH:19]=[CH:18][C:17]([O:30][CH3:31])=[C:16]([CH:21]=2)[CH2:15][NH:14][C@H:10]2[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]2[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1)#[N:29]Participants
3
Reactant 2
Product 1
Procedure
This compound was prepared from Compound 90 in the same manner of Compound 83.
Sources & evidence
- ORD record
- ord-6383eae5162544c3bc915780f710d2c7
- Source dataset
- uspto-grants-1998_08
- Patent number
- US05789423
Reaction notes
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