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HRID481588

反应详情

EQUATION

反应方程式

HRID 481588 的结构方程式

REACTANTS

反应物

4
结构：CO
HCID887

Methanol

CH4O

结构：O=C(O)C(=O)O
HCID971

Oxalic acid

C2H2O4

结构：Brc1cccc(N2CCNCC2)c1
HCID2757154

1-(3-Bromophenyl)piperazine

C10H13BrN2

结构：c1cc(OC[C@@H]2CO2)c2cc[nH]c2c1
HCID10943254

未命名化合物

PRODUCTS

生成物

1
结构：O=C(O)C(=O)O.O[C@H](COc1cccc2[nH]ccc12)CN1CCN(c2cccc(Br)c2)CC1
HCID131719673

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 1-(3-bromophenyl)piperazine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 84% overall yield. mp 144°-145°. FDMS m/e=429 (M+ of free base). α[D]589 =-8.12 (c=0.81, methanol).