反应详情

A solution of ethyl 3-[2-(2,2-diethylpropyl)benzoxazol-5-yl]propenoate (0.500 g, 0.00174 mol) in ethanol (30 ml) was hydrogenated at 4.0 bar (4×105 Nm−2) over 5% Pd on C for 4 hours at room temperature and then at 5.5 bar (5.5×105 Nm−2) for 6 hours. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with ethyl acetate:dichloromethane 3:97, to give ethyl 3-[2-(2,2-dimethylpropyl)benzoxazol-5-yl]propanoate (0.465 g).

1. customThe catalyst was removed by filtration
2. customthe filtrate was evaporated in vacuo
3. customThe residue was purified by flash column chromatography on silica gel
4. washeluting with ethyl acetate:dichloromethane 3:97