Ethyl 3-[2-(2,2-diethylpropyl)benzoxazol-5-yl]propenoate → Ethyl 3-[2-(2,2-dimethylpropyl)benzoxazol-5-yl]propanoate

Participants

Reaction Steps

A solution of ethyl 3-[2-(2,2-diethylpropyl)benzoxazol-5-yl]propenoate (0.500 g, 0.00174 mol) in ethanol (30 ml) was hydrogenated at 4.0 bar (4×105 Nm−2) over 5% Pd on C for 4 hours at room temperature and then at 5.5 bar (5.5×105 Nm−2) for 6 hours. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with ethyl acetate:dichloromethane 3:97, to give ethyl 3-[2-(2,2-dimethylpropyl)benzoxazol-5-yl]propanoate (0.465 g).

Provenance & Evidence