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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 481684Generated: October 27, 2026

Potassium Carbonate → HCID 21268240, compound

https://huagongshe.com/reaction/481684

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant6-trifluoromethyl-3-(piperidin-4-yl)-1H-indoleHCID 11149840—
Reactant4-(3-chloropropoxy)-1H-indoleHCID 11694169—
ProductHCID 21268240HCID 21268240—

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 192 from 6-trifluoromethyl-3-(piperidin-4-yl)-1H-indole (0.60 g, 2.2 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.65 g, 2.2 mmol) and potassium carbonate (0.46 g, 3.4 mmol). The product was isolated as a white foam. Yield 165 mg(17%). mp 92°-97° C. FDMS m/e=442 (M+ of free base).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05789402
Source datasetuspto-grants-1998_08
ORD IDord-71a2bcfaf96c4a3a81a35c360d07c077
Source noteuspto-grants-1998_08