Potassium Carbonate → HCID 21268240, compound

HRID 481684Notes

Reaction equation

HRID 481684 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:8][NH:9]2)=[CH:5][CH:4]=1.Cl[CH2:21][CH2:22][CH2:23][O:24][C:25]1[C:26]2[CH:27]=[CH:28][NH:29][C:30]=2[CH:31]=[CH:32][CH:33]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:19][C:2]([F:1])([F:18])[C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH:12]3[CH2:13][CH2:14][N:15]([CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:33]=[CH:32][CH:31]=[C:30]5[C:26]=4[CH:27]=[CH:28][NH:29]5)[CH2:16][CH2:17]3)=[CH:8][NH:9]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 111498406-trifluoromethyl-3-(piperidin-4-yl)-1H-indoleHCID 116941694-(3-chloropropoxy)-1H-indole

Product 1

HCID 21268240HCID 21268240, compound

Procedure

The title compound was prepared in a fashion similar to that described in Example 192 from 6-trifluoromethyl-3-(piperidin-4-yl)-1H-indole (0.60 g, 2.2 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.65 g, 2.2 mmol) and potassium carbonate (0.46 g, 3.4 mmol). The product was isolated as a white foam. Yield 165 mg(17%). mp 92°-97° C. FDMS m/e=442 (M+ of free base).

Workup

  1. customThe product was isolated as a white foam

Sources & evidence

ORD record
ord-71a2bcfaf96c4a3a81a35c360d07c077
Source dataset
uspto-grants-1998_08
Patent number
US05789402

Reaction notes

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