Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2s)-Glycidyl indol-4-yl ether → (2S)-(+)-3-[4-(5-fluoro-3-indolyl)piperidin-1-yl]-1-(4-indolyloxy)-2-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| 반응물 | 5-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11769929 | — |
| 용매 | Dimethyl sulfoxide methanol | HCID 22036561 | — |
| 생성물 | (2S)-(+)-3-[4-(5-fluoro-3-indolyl)piperidin-1-yl]-1-(4-indolyloxy)-2-propanol | HCID 70216375 | — |
반응 단계
The title compound was prepared in a fashion similar to that described in Example 193 from 5-fluoro-3-(piperidin-4-yl)-1H-indole (0.87 g, 4.0 mmol) and (S)-(+)-4-(oxiranylmethoxy)-1H-indole (0.76 g, 4.0 mmol). The product was isolated as a white foam. Yield 1.14 g (70%). mp 94°-97° C. FDMS m/e=407 (M+ of free base). α[D]589 =+8.36 (c=1.00, methanol/dimethylsulfoxide).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05789402 |
| 출처 데이터셋 | uspto-grants-1998_08 |
| ORD ID | ord-10863575a0dc473ea1663217adddb876 |
| 출처 메모 | uspto-grants-1998_08 |