反应详情

A 2-L three-necked flask equipped with a mechanical stirrer and an Ar-inlet tube was charged with 90.0 g (242 mmol) of ethyl triphenylphosphonium bromide and 480 mL of toluene. To the suspension, 27.2g (242 mmol) of potassium t-butoxide was added. After stirring at room temperature for 2 hr, the orange-red mixture was cooled with an ice-water bath. Then, 96.8 g (173 mmol) of (1α,3β)-3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-1-[(triethylsilyl)oxy]androsta-5,7-dien-17-one was added with the aid of 30 mL of toluene. The mixture was stirred at room temperature overnight, and the reaction was quenched by the addition of 3.96 mL of acetic acid (69 mmol). After stirring for an additional hour, the suspension was filtered through a Celite pad. The filter cake was washed with 2×130 mL of toluene. The combined filtrate and washes were concentrated, and the residual toluene was removed by co-evaporation with 180 mL of methanol followed by drying under high vacuum. The residue was then dissolved in a mixture of 350 mL of hexane and 350 mL of 95% methanol. The hexane layer was washed with 180 mL of 95% methanol. The combined methanol layers were extracted with 2×150 mL of hexane. The combined hexane solutions were dried over sodium sulfate (Na2SO4), and concentrated. The residual hexane was removed by co-evaporation with 30 mL of methanol. The resulting solid residue was suspended in 175 mL of methanol, and the suspension was stirred for 1 hr to obtain a powdery material. After the suspension was stored in a refrigerator overnight, the precipitate was filtered and washed with 2×175 mL of 95% methanol. Drying under high vacuum gave 91.1 g (92.9% yield) of (1α,3β,17Z)-dimethyl[[1-[(triethylsilyl)oxy]pregna-5,7,17(20)-trien-3-yl]oxy](1,1,2-trimethylpropyl)silane as an off-white solid.

1. customA 2-L three-necked flask equipped with a mechanical stirrer
2. temperaturethe orange-red mixture was cooled with an ice-water bath
3. stirringThe mixture was stirred at room temperature overnight
4. stirringAfter stirring for an additional hour
5. filtrationthe suspension was filtered through a Celite pad
6. washThe filter cake was washed with 2×130 mL of toluene
7. concentrationThe combined filtrate and washes were concentrated
8. customthe residual toluene was removed by co-evaporation with 180 mL of methanol
9. customby drying under high vacuum
10. dissolutionThe residue was then dissolved in a mixture of 350 mL of hexane and 350 mL of 95% methanol
11. washThe hexane layer was washed with 180 mL of 95% methanol
12. extractionThe combined methanol layers were extracted with 2×150 mL of hexane
13. dry with materialThe combined hexane solutions were dried over sodium sulfate (Na2SO4)
14. concentrationconcentrated
15. customThe residual hexane was removed by co-evaporation with 30 mL of methanol
16. stirringthe suspension was stirred for 1 hr
17. customto obtain a powdery material
18. customwas stored in a refrigerator overnight
19. filtrationthe precipitate was filtered
20. washwashed with 2×175 mL of 95% methanol
21. customDrying under high vacuum