反应详情

2-Chloroderivative (2) (0.5 mmol) and 3 ml of 3-aminopropanol were heated for 3 hours to 160° C. (sealed ampoule). Excess of the amine was evaporated at a temperature below 70° C. and the residue was purified by column chromatography (stepwise 0; 1; 2% MEOH in CHCl3) and crystallized from diethyl ether afforded the product in 82% yield; m.p. 98-101° C.

1. customExcess of the amine was evaporated at a temperature below 70° C.
2. customthe residue was purified by column chromatography (stepwise 0
3. custom2% MEOH in CHCl3) and crystallized from diethyl ether
4. customafforded the product in 82% yield