反应详情

To a solution of 4.29 gm (77 mmol) potassium hydroxide in 50 ml methanol were added 5.0 gm (26 mmol) 5-bromoindole and 7.84 gm (51 mmol) 4piperidone .HCl.H2O and the reaction mixture was stirred for 18 hours at reflux under a nitrogen atmosphere. The reaction mixture was cooled to ambient temperature, diluted with 500 ml water and the mixture extracted well with dichloromethane. The combined organic extracts were washed with water followed by saturated aqueous sodium chloride and dried over sodium sulfate. The remaining organics were concentrated under reduced pressure to give 6.23 gm (86.5%) of the title compound as a yellow oil.

1. temperatureat reflux under a nitrogen atmosphere
2. extractionthe mixture extracted well with dichloromethane
3. washThe combined organic extracts were washed with water
4. dry with materialdried over sodium sulfate
5. concentrationThe remaining organics were concentrated under reduced pressure