Methyl iodide → HCID 15449265, compound

HRID 481962Notes

Reaction equation

HRID 481962 reaction equation
[CH3:1][N:2]1[C:7](=[S:8])[NH:6][C:5]2[CH:9]=[CH:10][N:11]=[CH:12][C:4]=2[S:3]1(=[O:14])=[O:13].[C:15](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[CH3:1][N:2]1[C:7]([S:8][CH3:15])=[N:6][C:5]2[CH:9]=[CH:10][N:11]=[CH:12][C:4]=2[S:3]1(=[O:14])=[O:13]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 11128090HCID 11128090, compound

Product 1

HCID 15449265HCID 15449265, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2-methyl-3-thioxo-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (1.0 g) in acetonitrile (20 mL) was supplemented with potassium carbonate (1.0 g), then with methyl iodide (1 mL). After 1 h at room temperature, the solvent was removed by distillation under reduced pressure. The residue was dispersed in water (50 mL) and the suspension was adjusted to pH 5 with formic acid. The insoluble material was collected by filtration, washed with water and dried (yield: 0.8 g); m.p. 135°-138° C. (Compound V).

Workup

  1. customthe solvent was removed by distillation under reduced pressure
  2. additionThe residue was dispersed in water (50 mL)
  3. filtrationThe insoluble material was collected by filtration
  4. washwashed with water
  5. customdried (yield: 0.8 g)

Sources & evidence

ORD record
ord-788451bd1d994fb589384389474edda5
Source dataset
uspto-grants-1998_08
Patent number
US05792764

Reaction notes

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