反应详情

温度

120 °C

A mixture of 3-methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate (0.5 g) and allylamine (4 mL) was heated in a sealed bumb for 4-5 h at 120° C. After cooling, the amine was removed by distillation under reduced pressure. The residue was dissolved in 0.5N NaOH, treated with charcoal, filtered, and the filtrate was adjusted to pH 6 with 1N HCl. The resulting precipitate was collected by filtration, washed with water and dried to give the title compound as a dihydrate (yield: 0.44 g); m.p. 206°-208° C. (Compound 15).

1. temperatureAfter cooling
2. customthe amine was removed by distillation under reduced pressure
3. dissolutionThe residue was dissolved in 0.5N NaOH
4. additiontreated with charcoal
5. filtrationfiltered
6. filtrationThe resulting precipitate was collected by filtration
7. washwashed with water
8. customdried