反应详情

A solution of 11.4 g (0.1 mole) of methanesulfonyl chloride in 17.1 ml of dichloromethane is cooled to 5° C. A solution of 13 g (0.05 mole) of N,N-bis(2-hydroxyethyl)-4-methylbenzenesulfonamide and 10.1 g (0.1 mole) of triethylamine in 52 ml of dichloromethane is then added dropwise with stirring. The resulting mixture is allowed to return to ambient temperature and stirred for a further 3 hours. The reaction mixture is then extracted three times with 40 ml water. The organic phase is dried over sodium sulfate, filtered and concentrated in a rotating evaporator. The resulting oil is then crystallized from ethanol. 17.8 g of 4-methyl-N,N-bis[2-methylsulfonyloxy)ethyl]benzenesulfonamide are obtained.

1. customto return to ambient temperature
2. stirringstirred for a further 3 hours
3. extractionThe reaction mixture is then extracted three times with 40 ml water
4. dry with materialThe organic phase is dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in a rotating evaporator
7. customThe resulting oil is then crystallized from ethanol