反应详情

温度

25 °C

370 g (0.839 mole) of levorotatory (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine (prepared in Example 3.A1) and 405 g of 4-hydroxybenzoic acid are added to 1 liter of a 30% solution of hydrobromic acid in acetic acid. The suspension is stirred for 17 hours at 25° C. 2 liters of water are then added thereto and the suspension is cooled in an ice bath. The precipitate which forms is filtered and washed with 750 ml of water. 2 liters of toluene and 0.9 liters of a 50% aqueous solution of sodium hydroxide are then added to the filtrate. The organic phase is decanted off and washed with 100 ml of water and then once again with 1 liter of a saturated aqueous solution of sodium chloride. The organic phase is dried over sodium sulfate, filtered and the solvent evaporated off under reduced pressure. The residue is recrystallized from 600 ml of boiling hexane. The solution is filtered while hot, so as to remove any slightly insoluble material and the filtrate is then allowed to crystallize, first at ambient temperature, and then for 24 hours in an ice bath. The crystals are filtered off, washed with hexane and dried under vacuum at 40° C. 204.15 g of levorotatory (-)-1-[(4-chlorophenyl)phenylmethyl]piperazine are obtained.

1. temperaturethe suspension is cooled in an ice bath
2. filtrationThe precipitate which forms is filtered
3. washwashed with 750 ml of water
4. addition2 liters of toluene and 0.9 liters of a 50% aqueous solution of sodium hydroxide are then added to the filtrate
5. customThe organic phase is decanted off
6. washwashed with 100 ml of water
7. dry with materialThe organic phase is dried over sodium sulfate
8. filtrationfiltered
9. customthe solvent evaporated off under reduced pressure
10. customThe residue is recrystallized from 600 ml of boiling hexane
11. filtrationThe solution is filtered while hot, so as
12. customto remove any slightly insoluble material
13. customto crystallize, first at ambient temperature
14. waitfor 24 hours in an ice bath
15. filtrationThe crystals are filtered off
16. washwashed with hexane
17. customdried under vacuum at 40° C