HCID 19065568, compound → HCID 19065571, compound

HRID 482148Notes

Reaction equation

HRID 482148 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:13](=O)[CH2:14][CH2:15][C:16](=[O:18])[CH3:17])[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1>[OH-].[Na+]>[F:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:13]3[CH2:14][CH2:15][C:16](=[O:18])[CH:17]=3)[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 19065568HCID 19065568, compound

Product 1

HCID 19065571HCID 19065571, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 1-[3-(4-fluorophenoxy)phenyl]-1,4-pentanedione (19.03 g; 0.0665M) in 0.44M aqueous NaOH solution (300 ml) was refluxed for 24 hrs. After cooling, the residual solids were collected by filtration and dried to give 18 g (yield quant.) of the subtitle compound [D] as brown solids, which was used without further purification.

Workup

  1. temperatureAfter cooling
  2. filtrationthe residual solids were collected by filtration
  3. customdried
  4. customto give

Sources & evidence

ORD record
ord-84f5ff03857d401894cec7c07f5019ad
Source dataset
uspto-grants-1998_08
Patent number
US05792882

Reaction notes

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