反应详情

To a stirred solution of 3-[3-(4-fluorophenoxy)phenyl]-2-cyclopentenone (10 g; 0.0373M) in ethanol-pyridine (75 ml-21 ml) was added hydroxylamine hydrochloride (3.37 g; 0.0485M) at room temperature. After stirring for 4 hrs, solvent was removed. To the residue was added dilute aqueous HCl (100 ml), and the whole was extracted with ethyl acetate (200 ml×1, 100 ml×1). The combined organic layers were washed with water (100 ml), brine (100 ml), dried over MgSO4, and concentrated in vacuo to give 12 g of crude subtitle compound [E] as a brown oil, which was used without further purification.

1. customsolvent was removed
2. additionTo the residue was added dilute aqueous HCl (100 ml)
3. extractionthe whole was extracted with ethyl acetate (200 ml×1, 100 ml×1)
4. washThe combined organic layers were washed with water (100 ml), brine (100 ml)
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo