反应详情

A solution of the product from Example 82 (23.5 g, 58 mmol) in 30 mL fuming nitric acid and 150 mL trifluoroacetic acid was heated at 80° C. for 18 hours. The solvent was removed and the residue was treated with water to give a solid. The solid was collected by filtration and washed with ether and dried to give the title compound (9.5 g, 45% yield).

1. customThe solvent was removed
2. additionthe residue was treated with water
3. customto give a solid
4. filtrationThe solid was collected by filtration
5. washwashed with ether
6. customdried