HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 9-[2-(1-Imidazolyl)ethyl]-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole sulfuric acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 9-[2-(1-Imidazolyl)ethyl]-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole | HCID 19064088 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 9-[2-(1-Imidazolyl)ethyl]-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole sulfuric acid salt | HCID 19064087 | — |
Reaction Steps
A mixture of 9-[2-(1-imidazolyl)ethyl]-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole (I, EXAMPLE8, 0.334 g), sulfuric acid (0.5M, 1.73 mL), water (2 mL) and 2-propanol (20 mL) is warmed gently until the mixture becomes homogeneous. Following removal of the solvents at reduced pressure, the solid product is recrystallized from ethanol/acetone to give the title compound, mp=262°-263°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05795986 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-abbfd852f8cc4f00a080c5f8b126edf8 |
| Source note | uspto-grants-1998_08 |