反应详情

A mixture of 9-[2-(1-imidazolyl)ethyl]-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole (I, EXAMPLE8, 0.334 g), sulfuric acid (0.5M, 1.73 mL), water (2 mL) and 2-propanol (20 mL) is warmed gently until the mixture becomes homogeneous. Following removal of the solvents at reduced pressure, the solid product is recrystallized from ethanol/acetone to give the title compound, mp=262°-263°.

1. temperatureis warmed gently until the mixture
2. customremoval of the solvents at reduced pressure
3. customthe solid product is recrystallized from ethanol/acetone