反应详情

A mixture of the product from Example 87 (0.58 g, 2 mmol), benzylbromide (0.41 g, 2.4 mmol) and cesium carbonate (0.78 g, 2.4 mmol) in 10 mL of acetonitrile was stirred at room temperature for 2 hours. The triethylamine hydrobromide was removed by filtration and the filtrate evaporated. The residue was purified by silica gel chromatography (2:1 heptane:ethyl acetate as eluant) to give the title compound as a yellow solid (0.7 g, 91% yield).

1. customThe triethylamine hydrobromide was removed by filtration
2. customthe filtrate evaporated
3. customThe residue was purified by silica gel chromatography (2:1 heptane:ethyl acetate as eluant)