反应详情

A solution of the product from Example 92 (0.67 g, 1.7 mmol) in 20 ml tetrahydrofuran was treated with Raney nickel (0.1 g) and stirred under a hydrogen atmosphere (1 atm) for 48 hours. The Raney nickel was removed with a magnet and washed with methanol. The remaining solid was collected by filtration, washed with methanol and then dissolved in 2 N HCl and filtered. The filtrate was neutralized with saturated sodium bicarbonate and the precipitate collected by filtration and dried to give the title compound (0.30 g, 57% yield) mp>300° C.

1. customThe Raney nickel was removed with a magnet
2. washwashed with methanol
3. filtrationThe remaining solid was collected by filtration
4. washwashed with methanol
5. dissolutiondissolved in 2 N HCl
6. filtrationfiltered
7. filtrationthe precipitate collected by filtration
8. customdried