Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7,8,9,10-Tetrahydro-2,3-dimethoxy-6,8-dimethyl-pyrido[4,3-f]quinoxaline | HCID 10378594 | — |
| Product | HCID 22742474 | HCID 22742474 | 43% |
Reaction Steps
A solution of the product from Example 102 (0.172 g, 0.63 mmol) in 4 mL of aqueous 3N HCl solution was heated at reflux for 2 hours. The hot solution was treated with charcoal and filtered. The filtrate was cooled to 5° C. and the solid which formed was collected by filtration and dried at 90° C. under vacuum to give the title compound as a white solid (83 mg, 43% yield), mp=323-330° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06703391B2 |
|---|
| Source dataset | uspto-grants-2004_03 |
|---|
| ORD ID | ord-32c42046c4e64e3eb9e7620d8de6bb65 |
|---|
| Source note | uspto-grants-2004_03 |
|---|
