Methane → HCID 22742474, compound

HRID 48244Notes

Reaction equation

HRID 48244 reaction equation
C[O:2][C:3]1[C:4]([O:19]C)=[N:5][C:6]2[CH:7]=[C:8]([CH3:18])[C:9]3[CH2:16][N:15]([CH3:17])[CH2:14][CH2:13][C:10]=3[C:11]=2[N:12]=1.[ClH:21].C>>[ClH:21].[CH3:18][C:8]1[C:9]2[CH2:16][N:15]([CH3:17])[CH2:14][CH2:13][C:10]=2[C:11]2[NH:12][C:3](=[O:2])[C:4](=[O:19])[NH:5][C:6]=2[CH:7]=1

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 103785947,8,9,10-Tetrahydro-2,3-dimethoxy-6,8-dimethyl-pyrido[4,3-f]quinoxaline

Product 1

HCID 22742474HCID 22742474, compoundYield 43%

Conditions

Temperature
5 °C

Procedure

A solution of the product from Example 102 (0.172 g, 0.63 mmol) in 4 mL of aqueous 3N HCl solution was heated at reflux for 2 hours. The hot solution was treated with charcoal and filtered. The filtrate was cooled to 5° C. and the solid which formed was collected by filtration and dried at 90° C. under vacuum to give the title compound as a white solid (83 mg, 43% yield), mp=323-330° C.

Workup

  1. temperatureat reflux for 2 hours
  2. filtrationfiltered
  3. customthe solid which formed
  4. filtrationwas collected by filtration
  5. customdried at 90° C. under vacuum

Sources & evidence

ORD record
ord-32c42046c4e64e3eb9e7620d8de6bb65
Source dataset
uspto-grants-2004_03
Patent number
US06703391B2

Reaction notes

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