Boron tribromide → HCID 18981060, compound

HRID 482441Notes

Reaction equation

HRID 482441 reaction equation
[NH2:1][N:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5](=[O:12])[N:4]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)[C:3]1=[O:21].B(Br)(Br)Br>C(Cl)Cl>[NH2:1][N:2]1[C:7]([C:8]([F:10])([F:9])[F:11])=[CH:6][C:5](=[O:12])[N:4]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[C:3]1=[O:21]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 18981017HCID 18981017, compound

Product 1

HCID 18981060HCID 18981060, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By the method of Example 12, Step B, 1.0 gram (0.0033 mole) of 1-amino-3-(4-methoxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione and 2.5 grams (0.01 mole) of boron tribromide were reacted in 30 mL of methylene chloride, yielding 0.95 gram of 1-amino-3-(4-hydroxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione, m.p. 150°-155° C. The NMR spectrum was consistent with the proposed spectrum.

Sources & evidence

ORD record
ord-dba99e42dee447f48c0777056aa3abde
Source dataset
uspto-grants-1998_08
Patent number
US05798316

Reaction notes

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