Methyl chloroformate → 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenone

HRID 482611Notes

Reaction equation

[CH3:1][N:2](C)[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([F:15])[F:14])=[CH:8][CH:7]=1)=[O:5].Cl[C:18]([O:20][CH3:21])=[O:19]>>[CH3:1][N:2]([CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([F:14])[F:15])=[CH:8][CH:7]=1)=[O:5])[C:18]([O:20][CH3:21])=[O:19]

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 189809272-Dimethylamino-4'-difluoromethoxyacetophenone

Product 1

HCID 189809882-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenoneYield 60.2%

Procedure

By substantially following the procedure of Example 115b using 16.8 g (73 mmole) of 2-dimethylamino-4'-difluoromethoxy-acetophenone Example 126c and 7.6 g (81 mmole) of methyl chloroformate one obtain 12 g of 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenone an oil. bp 150°-190° C. at 0.7 torr.

Sources & evidence

ORD record: ord-90da2f8471534951819adb6563093ab8
Source dataset: uspto-grants-1998_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05798311

Reaction notes

Loading…