4-(Trifluoromethyl)phenyl isocyanate → HCID 18980989, compound

HRID 482622Notes

Reaction equation

HRID 482622 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]([N:13]([C:19]([O:21][CH3:22])=[O:20])[CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH2:11][NH:10][N:9]=2)=[CH:4][CH:3]=1.[F:23][C:24]([F:35])([F:34])[C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[O:33])=[CH:27][CH:26]=1>>[F:23][C:24]([F:34])([F:35])[C:25]1[CH:26]=[CH:27][C:28]([NH:31][C:32]([N:10]2[CH2:11][CH:12]([N:13]([C:19]([O:21][CH3:22])=[O:20])[CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[N:9]2)=[O:33])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 737684-(Trifluoromethyl)phenyl isocyanateHCID 18981010HCID 18981010, compound

Product 1

HCID 18980989HCID 18980989, compound

Procedure

By substantially following the procedure given in Example 585f using one third (≤13 mmole) of the solution of 3-(4-chlorophenyl)-4-(N-methoxycarbonyl-N-(carbomethoxymethyl)amino)-4,5-dihydro-1H-pyrazole (Example 487c) and 1.87 g (10 mmole) of 4-trifluoromethylphenyl isocyanate, 2.5 g of the desired compound, mp 198°-200° C. was obtained.

Sources & evidence

ORD record
ord-de8814b8898440248f9f79439749393a
Source dataset
uspto-grants-1998_08
Patent number
US05798311

Reaction notes

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