HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → 2-(1,2,4-Triazol-1-yl)-4'-propoxyacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Bromo-1-(4-propoxyphenyl)ethan-1-one | HCID 14617326 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(1,2,4-Triazol-1-yl)-4'-propoxyacetophenone | HCID 18980976 | 30.4% |
Reaction Steps
By substantially following the procedure of Example 608a using 29 g of 2-bromo-4'-propoxyacetophenone (Example 585b), 10 g of 1,2,4-triazole, 15 g (116 mmole) of diisopropylethylamine, and 100 ml of tetrahydrofuran, 8.4 g of the desired compound, mp 97°-99° C., was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05798311 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-a19d8a0e04e0412aa782ce27a61dd8e7 |
| Source note | uspto-grants-1998_08 |