1H-1,2,4-Triazole → 2-(1,2,4-Triazol-1-yl)-4'-propoxyacetophenone

HRID 482633Notes

Reaction equation

HRID 482633 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH3:14])=[CH:7][CH:6]=1)=[O:4].[NH:15]1[CH:19]=[N:18][CH:17]=[N:16]1.C(N(C(C)C)CC)(C)C>O1CCCC1>[N:15]1([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH3:14])=[CH:7][CH:6]=2)=[O:4])[CH:19]=[N:18][CH:17]=[N:16]1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 81531DiisopropylethylamineHCID 146173262-Bromo-1-(4-propoxyphenyl)ethan-1-one

Product 1

HCID 189809762-(1,2,4-Triazol-1-yl)-4'-propoxyacetophenoneYield 30.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By substantially following the procedure of Example 608a using 29 g of 2-bromo-4'-propoxyacetophenone (Example 585b), 10 g of 1,2,4-triazole, 15 g (116 mmole) of diisopropylethylamine, and 100 ml of tetrahydrofuran, 8.4 g of the desired compound, mp 97°-99° C., was obtained.

Sources & evidence

ORD record
ord-a19d8a0e04e0412aa782ce27a61dd8e7
Source dataset
uspto-grants-1998_08
Patent number
US05798311

Reaction notes

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