HRID482670

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8166

Dodecanoyl chloride

C12H23ClO

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CCCCCCCCCCCCCCCCCCNC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

HCID13361749

未命名化合物

HCID21881414

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCCN(C(=O)CCCCCCCCCCC)C1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

HCID13230937

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

10 g of the compound from Example 1 are suspended in 20 ml of tetrahydrofuran, 10 g of sodium carbonate are added and 10 g of dodecanoyl chloride in 10 ml of tetrahydrofuran are then added dropwise. When the reaction is complete (checked by thin layer chromatography on silica gel 60 6:1 toluene/isopropanol), the solid is filtered off, the filtrate is evaporated in vacuo to a syrup, and the crude product is purified by column chromatography on silica gel 60 using 10:1 toluene/isopropanol as the mobile phase.

WORKUP

后处理

filtrationthe solid is filtered off
customthe filtrate is evaporated in vacuo to a syrup
customthe crude product is purified by column chromatography on silica gel 60 using 10:1 toluene/isopropanol as the mobile phase

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3563ef59a36b44ba9e0cb0b1afeebd0a
来源数据集: uspto-grants-1986_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04574122
来源说明: uspto-grants-1986_03

反应 SMILES

[CH2:1]([NH:19][CH:20]1[O:28][C@H:27]([CH2:29][OH:30])[C@@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]1[OH:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].C(=O)([O-])[O-].[Na+].[Na+].[C:37](Cl)(=[O:49])[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].C1(C)C=CC=CC=1.C(O)(C)C>O1CCCC1>[CH:20]1([N:19]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:37](=[O:49])[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48])[O:28][C@H:27]([CH2:29][OH:30])[C@@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]1[OH:22]