反应详情

温度

0 °C

To a solution of 15.5 g. (0.0625 mole) of 3',4'-dihydro-7'-fluorospiro [imidazolidine-4,1'(2'H)-naphthalene]2,4',5-trione in 300 ml. of methanol cooled to 0° C. was added 4.8 g. (0.012 mole) of sodium borohydride over a period of 20 minutes. After stirring for one hour at 0° C. 100 ml. of 10% hydrochloric acid was added and the methanol removed under vacuum. The solid suspension was filtered and the solids dried, 7.3 g. (47% yield).

1. additionwas added 4.8 g
2. customthe methanol removed under vacuum
3. filtrationThe solid suspension was filtered
4. customthe solids dried