反应详情

20 g of 4-hydroxy-4'-biphenylcarboxylic acid, 53 g of (-)2-methylbutanol, and 4 g of conc. sulfuric acid were refluxed for 20 minutes, admixed with 500 ml of benzene, and heated in a container provided with a Dean-Stark reflux condenser. Generated water was removed. After the reaction mother liquor was cooled and washed with water, the solvent was distilled off to obtain crude 4-hydroxy-4'-biphenylcarboxylic acid 2-methylbutyl ester. The product was recrystallized from benzene-heptane mixed solvent to obtain a purified product having a melting point of 115° to 116° C.

1. temperatureheated in a container
2. customprovided with a Dean-Stark
3. temperaturereflux condenser
4. customGenerated water was removed
5. temperatureAfter the reaction mother liquor was cooled
6. washwashed with water
7. distillationthe solvent was distilled off