HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(Pyridin-4-yl)butane-1,3-dione → 5-Methyl-2-[4-(phenylmethyl)-1-piperazinyl]-7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(Pyridin-4-yl)butane-1,3-dione | HCID 12418330 | — |
| Edukt | 3-Amino-5-(4-benzyl-1-piperazinyl)-4-pyrazolecarbonitrile | HCID 178510493 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 5-Methyl-2-[4-(phenylmethyl)-1-piperazinyl]-7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 13579986 | — |
Reaktionsschritte
A mixture of 4.8 g (0.03 moles) of 1-(4-pyridyl)-1,3-butanedione [J. Chem. Soc. (1950) p 1680], 8.4 g (0.03 moles) of 3-amino-5-(4-phenylmethyl-1-piperazinyl)-4-pyrazolecarbonitrile (prepared as described in Example 1) and 100 ml of glacial acetic acid was stirred at reflux for 18 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04576943 |
| Quelldatensatz | uspto-grants-1986_03 |
| ORD ID | ord-1d687819fc27476e8de5e4cd036c4d90 |
| Quellennotiz | uspto-grants-1986_03 |