Hydrazine hydrate (1:1) → 3-Hydrazinyl-4-methyl-6-phenylpyridazine

HRID 482878Notes

Reaction equation

HRID 482878 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:7]=1[CH3:8].O.[NH2:16][NH2:17]>>[NH:16]([C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:7]=1[CH3:8])[NH2:17]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1199993-Chloro-4-methyl-6-phenylpyridazine

Product 1

HCID 30313733-Hydrazinyl-4-methyl-6-phenylpyridazine

Procedure

The mixture of 5 g of 3-chloro 4-methyl 6-phenyl pyridazine and 12 ml of hydrazine hydrate is taken to reflux. After one hour thirty minutes, the reaction medium is left to cool. A solid separates, which is drained and washed with a little water. The product is recrystallized in the mixture of isopropanol-isopropyl ether. Weight 4.5 g. m.p.: 162° C.

Workup

  1. temperatureto reflux
  2. waitthe reaction medium is left
  3. temperatureto cool
  4. washwashed with a little water
  5. customThe product is recrystallized in the mixture of isopropanol-isopropyl ether

Sources & evidence

ORD record
ord-4dd22a27249b4a83aa0c79ad3126ee8d
Source dataset
uspto-grants-1986_03
Patent number
US04576946

Reaction notes

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