HuagongsheHuagongshe Chemistry Print Report · For research reference only
Theophylline → 7-(6-Bromohexyl)-1,3-dimethylxanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Theophylline | HCID 2153 | — |
| Reactant | 1,6-Dibromohexane | HCID 12368 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | 7-(6-Bromohexyl)-1,3-dimethylxanthine | HCID 20244073 | — |
Reaction Steps
1,3-dimethylxanthine is dissolved in a mixture of 250 ml of water and 750 ml of n-propanol by adding an equimolar quantity of sodium hydroxide and heating. An equivalent amount of 1,6-dibromohexane is quickly added to the solution and the mixture is boiled under reflux for 1 hour. After evaporation of the n-propanol, 7-(6-bromohexyl)-1,3-dimethylxanthine is isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04576947 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-6d3bcbb674b14df191e141ce8b413deb |
| Source note | uspto-grants-1986_03 |