Imidazole → 4-(4-Methyl-1H-imidazol-1-yl)butan-1-amine

HRID 482903Notes

Reaction equation

HRID 482903 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1C(=O)C2=CC=CC=C2C1=O.[CH3:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1.C1(C2N=CN(CCCN)C=2)C=CC=CC=1.CC1N(CCCN)C=CN=1.C(C1N(CCCN)C=CN=1)C.N1C=CN=C1>>[CH3:17][C:18]1[N:19]=[CH:20][N:21]([CH2:2][CH2:3][CH2:4][CH2:5][NH2:6])[CH:22]=1

Participants

7

Reactant 6

HCID 795ImidazoleHCID 93575N-(4-Bromobutyl)phthalimideHCID 31521053-(2-methyl-1H-imidazol-1-yl)propan-1-amineHCID 64841343-(2-Ethyl-1H-imidazol-1-yl)-1-propanamineHCID 135889123-(4-Phenyl-1H-imidazol-1-yl)propan-1-amineHCID 178418800HCID 178418800, compound

Product 1

HCID 136181164-(4-Methyl-1H-imidazol-1-yl)butan-1-amine

Procedure

The procedure of Example 2 was repeated using N-(4-bromobutyl)phthalimide and 4-methyl-1H-imidazole giving the desired intermediate. Preparation of 4-phenyl-1H-imidazole-1-propanamine, 2-methyl-1H-imidazole-1-propanamine and 2-ethyl-1H-imidazole-1-propanamine was accomplished by the procedure of Example 4 using the appropriate imidazole starting materials.

Sources & evidence

ORD record
ord-041cf5eb75ec46f3a9051027e4bb4a81
Source dataset
uspto-grants-1986_03
Patent number
US04576957

Reaction notes

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