反应详情

A solution of 2.30 g. of o-chlorophenyl isocyanate in 30 ml. of toluene was added with stirring to a solution of 2.09 g. of 1H-imidazole-1-butanamine in 20 ml. of toluene and the mixture was allowed to stir overnight and them evaporates to a crystalline residue. The crystals were dissolved in methylene chloride and purified by HPLC (silica gel column, eluted with 10% ethanol/ethyl acetate) to obtain the desired compound, mp. 87°-88° C.

1. stirringto stir overnight
2. customthem evaporates to a crystalline residue
3. dissolutionThe crystals were dissolved in methylene chloride
4. custompurified by HPLC (silica gel column, eluted with 10% ethanol/ethyl acetate)