4-Chlorophenyl Isocyanate → HCID 13580011, compound

HRID 482907Notes

Reaction equation

HRID 482907 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[N:4][CH:3]=[N:2]1.O1CCCC1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]=[O:24])=[CH:18][CH:17]=1>C1(C)C=CC=CC=1>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:9][CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[O:24])=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 76934-Chlorophenyl IsocyanateHCID 8028TetrahydrofuranHCID 43796821H-1,2,4-Triazole-1-propanamine

Product 1

HCID 13580011HCID 13580011, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A 1.26 g. portion of 1H-1,2,4-triazole-1-propanamine was suspended in 15 ml. of toluene and 5 ml. of tetrahydrofuran was added to produce solution. A solution of 1.55 g. of freshly distilled p-chlorophenyl isocyanate in 15 ml. of toluene was added and the mixture was stirred overnight. The resulting crystals were recrystallized from toluene, giving 2.06 g. of the desired product, mp. 137°-139° C.

Workup

  1. customto produce solution
  2. customThe resulting crystals were recrystallized from toluene
  3. customgiving 2.06 g

Sources & evidence

ORD record
ord-eb062ae2d96d43448ca01ff5a66929cd
Source dataset
uspto-grants-1986_03
Patent number
US04576957

Reaction notes

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