Sulfuric acid magnesium salt (1:1) → HCID 13535826, compound

HRID 482958Notes

Reaction equation

HRID 482958 reaction equation
[CH3:1][CH:2]1[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1.[H][H].S([O-])([O-])(=O)=O.[Mg+2]>[Ni].O1CCCC1>[NH2:11][C:10]1[C:4]2[O:3][CH:2]([CH3:1])[CH2:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 135358252,3-Dihydro-2-methyl-7-nitrobenzofuranHCID 178418361HCID 178418361, compound

Product 1

HCID 13535826HCID 13535826, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 81 g of 1B, 400 ml of tetrahydrofuran (THF) and 3 g of activated Raney nickel catalyst was shaken under 35 p.s.i.g. hydrogen pressure at room temperature for 4 hours. The resulting mixture was treated with 20 g of magnesium sulfate, filtered and the solvent was evaporated from the filtrate, to give 7-amino-2,3-dihydro-2-methylbenzofuran (1C), as an amber syrup.

Workup

  1. filtrationfiltered
  2. customthe solvent was evaporated from the filtrate

Sources & evidence

ORD record
ord-5e300ed198aa443a82891f599d71acb8
Source dataset
uspto-grants-1986_03
Patent number
US04577011

Reaction notes

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