反应详情

A mixture of 13.6 g of aminoguanidine bicarbonate and 12.8 g of 2-acetyl butyrolactone in 80 ml of n-butanol was heated at reflux until a clear solution was obtained. This solution was cooled, evaporated to dryness in vacuo and the residue was triturated with 200 ml of a 50/50 ether-chloroform mixture, giving 12 g of the desired intermediate, mp 126°-135° C.

1. temperaturewas heated
2. temperatureat reflux until a clear solution
3. customwas obtained
4. temperatureThis solution was cooled
5. customevaporated to dryness in vacuo
6. customthe residue was triturated with 200 ml of a 50/50 ether-chloroform mixture