Benzaldehyde → HCID 178527993, compound

HRID 483020Notes

Reaction equation

HRID 483020 reaction equation
[NH2:1][N:2]1[C:6]([SH:7])=[N:5][N:4]=[N:3]1.[CH:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(O)C>[CH:8](=[N:1][N:2]1[C:6]([SH:7])=[N:5][N:4]=[N:3]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 1785142901-amino-1,2-dihydro-5H-tetrazole-5-thione

Product 1

HCID 178527993HCID 178527993, compoundYield 689.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.0 g of 1-amino-5-mercapto-1H-tetrazole and 0.6 g of benzaldehyde were dissolved in 120 ml of ethanol, and the solution was stirred at room temperature for 4 hours. After the reaction, the solution was evaporated to remove solvent. The residue was dissolved in 50 ml of ethyl acetate. The ethyl acetate solution was washed with water, dried and evaporated to remove solvent. Then, isopropyl ether was added to the residue obtained, and the crystalline precipitates were collected by filtration. 8.0 g of 1-benzylideneamino-5-mercapto-1H-tetrazole were obtained as colorless needles. mp 119°-120° C.

Workup

  1. customAfter the reaction
  2. customthe solution was evaporated
  3. customto remove solvent
  4. dissolutionThe residue was dissolved in 50 ml of ethyl acetate
  5. washThe ethyl acetate solution was washed with water
  6. customdried
  7. customevaporated
  8. customto remove solvent
  9. additionThen, isopropyl ether was added to the residue
  10. customobtained
  11. customthe crystalline precipitates
  12. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-049119fec04c48718ce57bdab05932b0
Source dataset
uspto-grants-1986_03
Patent number
US04576938

Reaction notes

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