Formic Acid → HCID 178502832, compound

Participants

Role	Name	HCID	Charge
Reactant	Formic Acid	HCID 284	—
Reactant	(6R,7R)-3-[(1-aminotetrazol-5-yl)sulfanylmethyl]-7-[[(2Z)-2-methoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid	HCID 178502831	—
Solvent	Water	HCID 962	—
Product	HCID 178502832	HCID 178502832	93.9%

Reaction Steps

To 80% formic acid (17 ml) was added 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid (4.3 g, 5.7 mmol) with stirring at room temperature and the mixture was stirred for an hour and a quarter. After adding water (85 ml), the mixture was filtered to remove insoluble material and the filtrate was concentrated below 45° C. The residue was treated with tetrahydrofuran (10 ml)-ether (5 ml) and concentrated again under reduced pressure. The residue was treated with ether to give pale yellow substances of 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid formate (2.98 g, 93.9%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04576938
Source dataset	uspto-grants-1986_03
ORD ID	ord-a0001485d4524b978b47addae3345c0b
Source note	uspto-grants-1986_03