反应详情

To a solution of sodium hydrogen bicarbonate (1 g, 12 mmol) in water (80 ml) were added 7β-aminocephalosporanic acid (3 g, 11 mmol) and 1-isopropylamino-5-mercapto-1H-tetrazole sodium salt (4 g, 22 mmol). The mixture was treated in a manner similar to that described in Example 6, (a) to give pale brown powder of 7β-amino-3-[(1-isopropylamino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid (2.7 g, 66%).

1. additionThe mixture was treated in a manner similar to