HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 3,3-Dimethoxythiane-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | ethyl 3-oxotetrahydro-2H-thiopyran-2-carboxylate | HCID 12269128 | — |
| Reactant | Methylorthoformate | HCID 53629101 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,3-Dimethoxythiane-2-carboxylic acid ethyl ester | HCID 54184102 | — |
Reaction Steps
To a mixture of 3-oxothiane-2-carboxylic acid ethyl ester (2.0 g), methanol (8 ml), and methyl orthoformate (20 ml) is added p-toluenesulfonic acid monohydrate (120 mg). After refluxing overnight, the mixture is concentrated, diluted with ethyl acetate, washed with water, dried, and concentrated to give 3,3-dimethoxythiane-2-carboxylic acid ethyl ester (1.32 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578378 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-20d8115fdcc24caab29ad2475c01bf02 |
| Source note | uspto-grants-1986_03 |