反应详情

To a mixture of 3-oxothiane-2-carboxylic acid ethyl ester (2.0 g), methanol (8 ml), and methyl orthoformate (20 ml) is added p-toluenesulfonic acid monohydrate (120 mg). After refluxing overnight, the mixture is concentrated, diluted with ethyl acetate, washed with water, dried, and concentrated to give 3,3-dimethoxythiane-2-carboxylic acid ethyl ester (1.32 g).

1. temperatureAfter refluxing overnight
2. concentrationthe mixture is concentrated
3. additiondiluted with ethyl acetate
4. washwashed with water
5. customdried
6. concentrationconcentrated