1-Phenyl-1-propanone → 2-Bromopropiophenone

HRID 483117Notes

Reaction equation

HRID 483117 reaction equation
[Br:1]Br.[C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])[CH2:4][CH3:5]>ClCCl>[Br:1][CH:4]([CH3:5])[C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6]

Participants

4

Reactant 2

HCID 71481-Phenyl-1-propanoneHCID 24408Bromine

Product 1

HCID 164522-Bromopropiophenone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 82 g (0.51 mol) of bromine in 100 ml of dichloromethane is added dropwise to a solution of 72 g (0.5 mol) of propiophenone in 500 ml of dichloromethane, at 20° C. After 30 minutes, the solution is evaporated down. 2-Bromopropiophenone is obtained quantitatively, and is directly reacted further.

Workup

  1. customthe solution is evaporated down

Sources & evidence

ORD record
ord-1abad804cba54e4eb7458e2871fff61b
Source dataset
uspto-grants-1986_03
Patent number
US04578396

Reaction notes

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